無症状の潜伏期に会話で感染する新型コロナは免疫抑制式時限爆弾
無症状の潜伏期に会話で感染する新型コロナは免疫抑制式時限爆弾
◆免疫を抑制するから感染しても無症状
新型コロナウイルスが弱いウイルスだから無症状なのではない。
感染した人の免疫が強いから症状がでないのでもない。
新型コロナウイルスが人体の免疫を抑制するので、
感染したのに自覚症状がでないのである。
◆新型コロナウイルスという時限爆弾の工作員
無症状だから時限爆弾がしかけられたことに気がつかない
◆発声は咳と同じ
※発声は咳と同じく破裂音と摩擦音で破擦音
咳のハクション
ハ
ック ：舌の奥と軟口蓋による破裂音
ショ ：舌と歯茎から硬口蓋の間の摩擦音
ン
会話中の歓声
キャー ：舌の奥と軟口蓋による破裂音で開始
ヒャー ：舌と硬口蓋の間の摩擦音で開始
◆ハクションは英語でアチュー（Atchoo!）
アッチューのチュは
舌と歯茎から硬口蓋の間の
破裂音と摩擦音による破擦音
◆細胞の免疫を抑制して無症状
新型コロナウイルスに感染しても
症状がないので自覚がない。
その無症状の人が、誰かと近距離で会話すると、
マイクロ飛沫が口から空中に出て、
それを吸いこんだ人に感染する。
うつした人もうつされた人も発症するまで
時限爆弾に気がつかない
◆コロナウイルスはACE２に結合し細胞に侵入して増殖
新型コロナウイルスは人体の細胞表面のACE２に結合し
そのRNAが細胞内に入る。細胞の中でウイルスの複製が
行われ、ウイルスは増殖する。
◆新型コロナウイルスは免疫を抑制する
細胞にウイルスが感染すると、免疫が正常であれば
細胞内にサイトカインやインターフェロンが産生される。
マクロファージからもサイトカインがでて発熱する。
そして感染した細胞をリンパ球が破壊するので
痛みを感じる。
ところが新型コロナウイルスはRNAとなって細胞内に侵入すると
サイトカインやインターフェロンの産生を抑制してしまう。
免疫細胞を呼ぶサイトカインなどが放出されないと、
感染場所にリンパ球（細胞障害性Ｔ細胞）は集まらない。
免疫を担当する細胞が攻撃しないので、症状がでない。
◆最初はマクロファージなどによる自然免疫
マクロファージがウイルスを貪食
↓
マクロファージからインターロイキンなどの
サイトカイン
↓
サイトカインが脳の血液脳関門の手前まで流れる
↓
サイトカインによってプロスタグランジンE2
↓
プロスタグランジンE2が視床下部の
体温調節中枢に作用すると
発熱
◆時限爆弾を止めないと爆発してARDS
発症者をみつけ、それが時限爆弾のような
新型コロナウイルス感染症だったら、
そのカウントダウンを止めないと
ARDSに進行してしまう
COVID-19時限爆弾のカウントダウン
[028] 集団の1人が感染するが無症状
[021] 集団の複数の人に感染がひろがる
[014] 症状がないので、感染した自覚なく普通に生活
[007] 7日前に発熱、倦怠感などの初発症状が出現 ARDSの一週間前
※回復しない場合は、発症から約一週間でARDS
◆時限爆弾のカウントダウンを止められる薬
※アビガン
※イベルメクチンもウイルスの増殖を抑制できる
※フサンはウイルスが細胞内に侵入するのを
抑制するので、時限爆弾が入った細胞が増えない。
◆特定なウイルスによる感染細胞を破壊する細胞障害性T細胞（獲得免疫）
ウイルスを貪食したマクロファージは
表面にMHCクラスⅠで抗原提示
↓
抗原提示細胞がリンパ節でTリンパ球を活性化
ウイルスの抗原に対する特異性あるTCRを持った
Tリンパ球（エフェクター細胞）が分裂増殖
↓
増加したTリンパ球はリンパ節から出て、胸管を経由して
全身の血管へ流れていく
サイトカインによって
リンパ球が集まる
↓
ウイルスが感染した肺胞上皮細胞などをみつけると
細胞傷害性T細胞はそれを攻撃する。
細胞傷害性T細胞から放出された
パーフォリンが細胞に孔をあけ、
爆弾のようなグランザイムが細胞内に投げ入れられると
細胞はアポトーシスをおこして破壊され消失する。
◆時限爆弾が爆発してARDS(急性呼吸窮迫症候群）
細胞障害性Ｔ細胞が新型コロナウイルスに感染した
肺胞上皮細胞を攻撃。
肺胞上皮細胞からサーファクタントがでなくなり、肺胞は虚脱。
血管透過性が亢進して血管からの滲出が肺胞の周囲にたまる。
肺胞から血管へ酸素が拡散しなくなって呼吸困難。
This work was supported by funding from the Department of Veterans Affairs I01BX004939 PDK, Research Career Scientist Awards IK6BX005233 NSP and 15F RCS 001 SJF; the NIH R24EY027283 KP, PDK, SB, and NSP, R01EY009339 KP, P30EY025585 NSP, R01EY029341 SJF, F30EY029136 SS, and T32GM008803 EHC; National Center for Advancing Translational Sciences NIH grant 1UL1 TR001412 SJF; and unrestricted grants from Research to Prevent Blindness to the Departments of Ophthalmology at University of California, Irvine, and Cleveland Clinic Lerner College of Medicine propecia and rogaine
whoah this weblog is magnificent i love studying your articles.
Stay up the great work! You realize, a lot of people are searching
around for this information, you can help them greatly.
https://mbio.me/bbs/board.php?bo_table=free&wr_id=326360
Hi there! Someone in my Facebook group shared this site with us so I came to give it a look.
I’m definitely loving the information. I’m bookmarking and will be tweeting this to my followers!
Excellent blog and terrific design.
Thanks for finally writing about > 無症状の潜伏期に会話で感染する新型コロナは免疫抑制式時限爆弾 | 多摩境内科クリニック < Liked it!
Outstanding post however , I was wanting to know if you could
write a litte more on this topic? I’d be very
thankful if you could elaborate a little bit further.
Bless you!
Heya i’m for the first time here. I found this board and I find It truly useful & it helped me out a lot.
I hope to give something back and aid others like you helped me.
My brother recommended I might like this blog. He was entirely
right. This post truly made my day. You cann’t imagine just how much time I had spent for this information! Thanks!
It’s actually a cool and useful piece of information. I am happy that you
shared this helpful information with us. Please stay us informed
like this. Thanks for sharing.
Today, I went to the beach with my kids. I found a sea shell and gave
it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the
shell to her ear and screamed. There was a hermit crab inside and it pinched
her ear. She never wants to go back! LoL I know this is entirely off topic but I had to tell someone!
I go to see every day a few blogs and information sites to read posts, but this web site
offers feature based articles.
Hi there friends, good piece of writing and pleasant arguments commented
here, I am truly enjoying by these.
Simply want to say your article is as surprising.
The clarity in your submit is simply spectacular and i can assume you’re an expert on this subject.
Fine together with your permission allow me to snatch your RSS feed to stay up to date with
coming near near post. Thank you 1,000,000
and please keep up the rewarding work.
whoah this weblog is wonderful i really like reading your posts.
Stay up the great work! You understand, a lot of people are
looking round for this information, you can help
them greatly.
Every weekend i used to pay a visit this web site, for the reason that i
want enjoyment, since this this website conations actually nice
funny information too.
http://www.atube.co.kr/bbs/board.php?bo_table=free&wr_id=54591
Hmm it seems like your site ate my first comment (it was super long)
so I guess I’ll just sum it up what I wrote and say, I’m thoroughly enjoying your blog.
I as well am an aspiring blog blogger but I’m still new to everything.
Do you have any helpful hints for beginner blog writers?
I’d certainly appreciate it.
Write more, thats all I have to say. Literally, it
seems as though you relied on the video to make your point.
You obviously know what youre talking about, why waste your
intelligence on just posting videos to your blog when you could be giving us something informative to
read?
I am really inspired with your writing abilities and also with the layout
to your weblog. Is that this a paid topic or did you customize it yourself?
Either way keep up the nice high quality writing,
it’s uncommon to look a great blog like this one these days..
Excellent post. I am dealing with a few of these issues as well..
Whats up this is kind of of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML.
I’m starting a blog soon but have no coding knowledge so I wanted to get advice from someone with experience.
Any help would be enormously appreciated!
Hello, Neat post. There’s a problem with your web site in web explorer,
might test this? IE still is the marketplace chief and a big component to
other people will omit your excellent writing because of this problem.
Everyone loves what you guys are up too. Such clever work and
reporting! Keep up the wonderful works guys I’ve added you guys to my own blogroll.
Excellent beat ! I would like to apprentice even as you amend your site,
how can i subscribe for a weblog web site? The account aided
me a acceptable deal. I were a little bit acquainted of this
your broadcast provided vibrant transparent concept
Hello, I log on to your blog regularly. Your humoristic style is
awesome, keep up the good work!
This post offers clear idea for the new people of blogging, that in fact how to do
blogging.
What’s Taking place i’m new to this, I stumbled upon this I’ve found
It absolutely useful and it has aided me out loads.
I hope to give a contribution & assist different users like
its aided me. Good job.
Hello! Someone in my Myspace group shared this site with us so I came to look it over.
I’m definitely loving the information. I’m bookmarking and will be tweeting this to my followers!
Exceptional blog and excellent design and style.
Asking questions are really pleasant thing if you are not understanding something
fully, however this piece of writing gives good understanding yet.
Excellent blog here! Also your website loads up very fast!
What host are you using? Can I get your affiliate link
to your host? I wish my website loaded up as fast as yours lol
Pretty! This was an extremely wonderful post. Many thanks for supplying these details.
Link exchange is nothing else but it is only placing the other person’s
blog link on your page at appropriate place and other person will
also do same for you.
These are really enormous ideas in about blogging.
You have touched some nice things here. Any way keep up wrinting.
I’ve been browsing online greater than 3 hours today, but I
never discovered any attention-grabbing article like yours.
It’s pretty price sufficient for me. Personally, if all
site owners and bloggers made just right content as you
probably did, the web shall be a lot more helpful than ever before.
Wonderful article! We will be linking to this particularly great article on our website.
Keep up the good writing.
A person essentially help to make critically articles I might state.
This is the first time I frequented your web page and
to this point? I amazed with the analysis you made to create this particular submit incredible.
Wonderful task!
Amazing! Its genuinely remarkable article, I have got much
clear idea on the topic of from this paragraph.
Hi there Dear, are you actually visiting this site on a regular basis, if so
afterward you will definitely take nice know-how.
Thanks , I’ve just been searching for info about this topic for ages and yours is the
greatest I have discovered so far. But, what about the bottom line?
Are you positive about the source?
I couldn’t refrain from commenting. Very well written!
Greetings from Colorado! I’m bored at work so I decided to check out your
blog on my iphone during lunch break. I really like the info you present here and can’t wait to take a look when I get home.
I’m surprised at how quick your blog loaded on my cell phone ..
I’m not even using WIFI, just 3G .. Anyways, superb blog!
Undeniably believe that which you said. Your favourite reason appeared to be at the internet
the easiest factor to remember of. I say to you, I certainly get annoyed at the same time as folks think about issues that they
plainly do not understand about. You controlled to hit
the nail upon the top and defined out the entire thing with no
need side-effects , other folks can take a signal.
Will likely be back to get more. Thanks
Very descriptive article, I loved that bit. Will there be a part
2?
I pay a visit day-to-day a few websites and sites to read articles, but this webpage gives feature based content.
I’m gone to inform my little brother, that he should also visit this blog on regular basis to
get updated from most up-to-date news.
Good post. I learn something totally new and challenging
on blogs I stumbleupon everyday. It will always be exciting to read articles from other authors and use something from other web sites.
Great article. I am going through a few of these issues as well..
Thank you for sharing your thoughts. I really appreciate
your efforts and I will be waiting for your next post thanks once again.
Great post. I used to be checking continuously
this weblog and I’m impressed! Very helpful information specially the remaining section 🙂 I
deal with such info a lot. I was looking for this particular info for a long time.
Thanks and good luck.
Hurrah! At last I got a webpage from where I can actually get helpful
data concerning my study and knowledge.
http://xn--o01bq9wunc92bgw3a.xn--3e0b707e/bbs/board.php?bo_table=free&wr_id=764932
I will immediately grab your rss feed as I can’t find your e-mail subscription link or
e-newsletter service. Do you have any? Kindly allow me
understand in order that I could subscribe. Thanks.
I’m amazed, I have to admit. Rarely do I come across a blog
that’s both equally educative and entertaining, and let me tell you,
you’ve hit the nail on the head. The problem
is an issue that not enough men and women are speaking intelligently about.
I’m very happy I came across this during my hunt for something relating to this.
I read this article fully concerning the difference of most
recent and earlier technologies, it’s remarkable article.
Woah! I’m really digging the template/theme of this blog.
It’s simple, yet effective. A lot of times it’s tough to get that “perfect balance” between superb usability and appearance.
I must say you’ve done a very good job with
this. In addition, the blog loads very fast for me on Safari.
Outstanding Blog!
Do you have a spam issue on this website; I also am a blogger, and I was wanting to know your situation; we have developed some nice
practices and we are looking to exchange solutions with other folks, be
sure to shoot me an email if interested.
If you desire to obtain a great deal from this post then you have
to apply these strategies to your won web site.
I all the time emailed this webpage post page to all my friends, as if like
to read it next my friends will too.
Informative article, exactly what I was looking for.
Hi, I wish for to subscribe for this webpage to get latest updates, so where can i do it please assist.
Very nice post. I just stumbled upon your weblog and wanted to say that I have really enjoyed surfing around your blog posts.
In any case I will be subscribing in your rss feed and I’m hoping you write again soon!
Your mode of describing all in this paragraph is really good, every
one be capable of effortlessly be aware of it, Thanks a lot.
I do consider all the ideas you’ve presented to your post.
They are very convincing and will certainly work.
Still, the posts are very short for novices. Could you please lengthen them a bit
from subsequent time? Thanks for the post.
Hi there, I enjoy reading through your article. I wanted to write a little comment
to support you.
Pretty nice post. I just stumbled upon your weblog and wished to say that I have truly enjoyed surfing around your blog posts.
In any case I’ll be subscribing to your rss feed and I hope you write again very soon!
http://www.epoorun.com/bbs/board.php?bo_table=free&wr_id=28794
https://sincere-platypus-lw642b.mystrikingly.com/blog/steer-clear-of-online-casino-scams
Every weekend i used to pay a quick visit this website, for the reason that i want enjoyment, for the
reason that this this website conations truly pleasant funny
stuff too.
Hi! Someone in my Myspace group shared this website with us so I came to
give it a look. I’m definitely loving the information. I’m book-marking and will be tweeting this to my followers!
Terrific blog and wonderful design and style.
Keep this going please, great job!
This is really interesting, You are a very skilled
blogger. I have joined your rss feed and look forward to seeking more of your magnificent post.
Also, I have shared your site in my social
networks!
If some one wants to be updated with newest technologies therefore
he must be go to see this website and be up to date all the time.
What i don’t realize is in reality how you are now not actually a lot more neatly-favored than you may be right
now. You’re very intelligent. You realize therefore significantly in relation to this matter,
produced me individually believe it from a lot of numerous angles.
Its like men and women are not fascinated until
it is something to accomplish with Woman gaga! Your individual stuffs excellent.
All the time care for it up!
Hi to every one, as I am genuinely keen of reading this webpage’s
post to be updated regularly. It includes fastidious information.
Today, while I was at work, my sister stole my apple ipad and tested to see if it can survive a thirty foot drop,
just so she can be a youtube sensation. My apple ipad
is now broken and she has 83 views. I know this is completely off topic but I had to share it with someone!
Hello everyone, it’s my first pay a visit at this web site, and paragraph is genuinely fruitful in favor
of me, keep up posting these posts.
Bank customers who prefer financing without using collateral.
my blog post; Loan for Unemployed
I am regular visitor, how are you everybody? This post posted
at this web page is really fastidious.
I think this is one of the so much significant info for me.
And i’m happy studying your article. However want to observation on some general issues, The web site taste is ideal, the
articles is truly great : D. Excellent task, cheers
The other day, while I was at work, my sister stole my iphone and tested to see
if it can survive a forty foot drop, just so she can be a youtube sensation.
My iPad is now destroyed and she has 83 views.
I know this is entirely off topic but I had to share it with someone!
I was recommended this web site by my cousin. I am not
sure whether this post is written by him as
no one else know such detailed about my problem.
You are amazing! Thanks!
It’s very trouble-free to find out any topic on web as compared
to textbooks, as I found this article at this web site.
Financing a house is a decision that shouldn’t be taken flippantly.
Visit my web blog … dev.ccwin-in.com
Yes! Finally something about Hokicoy.
It’s remarkable in support of me to have a website, which is beneficial designed for my know-how.
thanks admin
Hi there to all, how is all, I think every one is getting more from this web page, and your views
are good designed for new visitors.
Hello! I simply want to give you a huge thumbs up
for your excellent information you have here on this post.
I’ll be coming back to your site for more soon.
Just wish to say your article is as amazing. The clarity in your
post is just great and i could assume you are an expert on this subject.
Well with your permission allow me to grab your feed to keep up to
date with forthcoming post. Thanks a million and
please continue the enjoyable work.
Saved as a favorite, I love your blog!
I am in fact glad to glance at this weblog posts which consists of lots of helpful information, thanks for providing these kinds of information.
I am really impressed along with your writing skills
as well as with the layout in your blog. Is that this a paid topic or did you customize it your self?
Either way keep up the nice high quality writing, it is uncommon to peer a
great blog like this one nowadays..
Hello, Neat post. There is a problem together with your website in internet explorer, might test
this? IE nonetheless is the market leader and a good part
of folks will pass over your wonderful writing because of this problem.